Professor Bill MacNee

Professor Bill MacNee

Professor of Respiratory and Environmental Medicine/Honorary Consultant Physician

Type of staff member: Principal Investigator
Research Theme: Immune Modulation and Regulation of Inflammation
Qualifications: MBChB MD FRCP(G) FRCP(E)
Group members:

Dr Ellen Drost (Senior Post-doctoral Research Fellow)
Dr Roberto Rabinovich (Clinical Fellow)
Andrew Deans (Research Nurse)
Susie Ferguson (Research Nurse)
Leandro Mantoani (PhD student)

Research career began as an MRC Research Fellow in the Department of Respiratory Medicine, University of Edinburgh where I studied the functional consequences of pulmonary hypertension in Chronic Obstructive Pulmonary Disease (COPD) including measurements of right ventricular mechanics which led to an MD thesis of "Right ventricular function in chronic bronchitis and emphysema". In these studies I also developed and validated the methodology to diagnosis and quantify pulmonary emphysema by CT scanning.

My research training continued as an MRC Travelling Fellowship in the University of British Columbia, Pulmonary Research Laboratory where I developed an interest in cell biology of lung diseases. I developed techniques to assess neutrophil trafficking in the lungs.  These studies resulted in new concepts of how neutrophils traverse the pulmonary micro circulation and showed profound effect of smoking and COPD has on these cells.  My interest in cell molecular biology inflammation continued on my return to the University of Edinburgh and in collaboration with colleagues in Edinburgh and elsewhere to assess leukocyte function in human man and animal models and to the study of oxidant and antioxidant balance in the lungs and its relationship to the pathogenesis of COPD.  I also developed an interest in the mechanisms of the harmful effects of air pollutants and other particulates in the lungs and the mechanisms of the adverse cardiovascular effects of air pollutants.

Research Overview:

Current research continues on the study of pathogenic mechanisms in COPD.  In particular we have been studying the mechanisms of systemic effects of COPD, both the mechanisms related to the increased cardiovascular risk in COPD and the muscle dysfunction in COPD.  These studies involve both in vivo studies in COPD patients assessing endothelial function and changes in muscle function and in vitro studies using cells obtained from COPD subjects.

Selected Publications:


Funding Acknowledgements:


This page was last modified on 31 March, 2016