Welcome to the MRC Centre for Inflammation Research

State of the Art Imaging

CIR Imaging Suite including confocal microscopy and flow cytometry services. State of the art clinical and small mammal molecular imaging: MRI, CT, PET.

Find out more about imaging...
Scientist training in lab
Training

Training clinical and non-clinical scientists in the molecular, cell and tissue biology of inflammatory and immune processes.

Find out more about training...
QMRI building
MRC Centre for Inflammation Research

A multidisciplinary centre of excellence; Internationally outstanding researchers developing novel approaches of diagnosis, prevention and treatment

Read more about research...
Research

Three key thematic areas: Immune Modulation and Regulation of Inflammation; Tissue Remodelling and Regeneration; and Imaging Inflammation.

Find out more about our research...
Athena SWAN silver award logo
Deanery of Clinical Sciences: Athena SWAN Silver status

The CIR strives to promote a culture of respect and nurtures excellence, leadership and innovation and inclusion of people from all backgrounds

The Athena SWAN Award
Scientist training in lab
QMRI building
Athena SWAN silver award logo

The University of Edinburgh / Medical Research Council (MRC) Centre for Inflammation Research (CIR) is a multidisciplinary centre in which clinical and non-clinical scientists prosecute internationally competitive research to identify targets and deliver translational benefits. Additionally, the Centre is a highly fertile environment for the training of scientific and medical graduates in inflammation biology. Our College of Medicine and Veterinary Medicine ranked outstanding in the recent UK REF2014 research assessment.

MRC-CIR Image of the Month
July 2016

Haematopoietic stem cells (HSCs) emerge from blood vessels at embryonic day 10.5 (E10.5) in the embryonic organ aorta-gonad-mesonephros (AGM) region before they reside in the bone marrow. BMP4 pathway is one of the important pathways, playing a role in the HSC development in the AGM region. HSCs are also found in the E10.5 mouse embryonic head. Recently, by sub-dissecting mouse embryonic head, Zhuan Li et al. of Elaine Dzierzak’s group have observed that HSCs are localized in the hind brain with attached brachial arches (HBA) part of the head. Here is shown a whole mount image of an E11 HBA from BMP pathway responsive element (BRE-GFP) transgenic mouse embryonic head, where BMP activated cells are labelled with green fluorescence. In this image, endothelial cells (labelled by CD31, red) and BMP pathway activated cells (BRE-GFP; green) are found to be coexpressed (yellow) in the embryonic hind brain region. Thus, demonstrating that some portion of endothelial cells in the head are BMP pathway activated, indicating that BMP pathway may be involved in the regulation of HSC development in the head region. The picture was acquired with a Leica SP5 confocal. Instrument located at the CIR, QMRI.


View more images from MRC-CIR.
This page was last modified on 12 April, 2016